Journal: bioRxiv
Article Title: A Continuously Oxygenated Macroencapsulation System Enables High-Density Packing and Delivery of Insulin-Secreting Cells
doi: 10.1101/2025.04.21.649806
Figure Lengend Snippet: The system comprises two integral components: an implantable electrochemical oxygen generator (iEOG) and a core-shell cell encapsulation pouch designed in linear configuration to facilitate minimally invasive implantation, connected by gas-impermeable tubing. ( A ) Schematic representation illustrating oxygen generation by electrolytic splitting of tissue moisture. A human sketch is shown to indicate the relative size of a human version system. (The power supply needed for electrolysis is not shown) ( B ) A representative digital image of a scaled-up BEAM system with a cell encapsulation pouch measuring 15 cm in length and 5 mm in thickness. ( C ) Longitudinal section view of the cell encapsulation pouch showing pancreatic islets located in the annular space between an inner silicon tubing and the semipermeable membrane for optimal mass transportation and proximity between cells and the oxygen source.
Article Snippet: The oxygen transportation tubing is composed of two distinct segments: an oxygen-permeable segment constructed from USP class VI silicone tubing with an I.D. of 0.635 mm and an outer diameter O.D. of 1.194 mm (Specialty Manufacturing Inc), and an oxygen-impermeable segment fabricated from medical-grade polyurethane tubing with an I.D. of 1.016 mm and an O.D. of 1.379 mm (Scientific Commodities Inc).
Techniques: Encapsulation, Electrolysis, Membrane